MOLECULAR CYTOGENETICS (FISH)

It is a genetic analysis method in which changes such as chromosomal microdeletions and translocations that cannot be detected by classical cytogenetic analysis are examined with fluorescent dyes called probes. The result is achieved with probes designed specifically for the region where the change is expected. Microdeletion Syndromes are a group of diseases that cause multiple system-related disorders and dysmorphic facial findings due to losses of approximately 1-3 million bases in the chromosomal region. Since classical cytogenetic examinations will result in normal results in this disease group, molecular cytogenetic examination must be performed. In addition, since it can detect the presence of numerical chromosomal anomaly quickly, it is used in the prenatal diagnosis as well as in order to perform the diagnosis and treatment in hematological cancers quickly.

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