DRUG INTERACTIONS (Pharmocogenetics)

It has been known for a long time that some genetic polymorphisms have an effect on drug metabolism. While some of these genetic polymorphisms increase the possibility of side effects by decreasing the rate of degradation of drugs in the liver and prolonging their stay in the body, some polymorphisms do not allow the drug to show its effect because it causes the drug to be quickly eliminated from the body. For example; investigation of polymorphisms in the DPD gene for 5-fluorouracil, a chemotherapy drug, is very critical to prevent possible side effects in patients with a long degradation time.

 

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